4P Pharma offers a wide range of preclinical inflammatory models and consultancy expertise in the preclinical inflammatory area. We develop flexible, tailored preclinical programs designed to each therapeutics specificity, from in vitro drug screening to experimental inflammatory models in animals.

Acute and chronic inflammation are the cause of severe complications and an established risk factor for life-threatening conditions, including cancer, cardiovascular diseases and stroke.

For every R&D studies performed, we ensure an intercross between in vitro, in vivo and ex vivo models along with unbiased laboratory, species and model independency.

Acute inflammation models

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Carrageenan-induced acute inflammation model in rats

Formalin induced sub-acute inflammation test in mice

Cotton pellet-induced granuloma test in rats

Delayed-type hypersensitivity model in mice (DTH)

Peritonitis model in mice (Macrophages Migration)

Lung fibrosis model in mice (Bleomycin induced)

Corton oil induced ear inflammation

Chronic inflammation models

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⊕ Intestinal Bowel Disease Models

DSS-induced colitis in mice (Balb/c, C57Bl/6)

TNBS-induced colitis in mice

⊕ Rheumatoid Arthritis models

Collagen-induced arthritis model in rats/mice

⊕ Osteoarthritis models

CFA-induced osteoarthritis model in rats

Induction of osteoarthritis model by transaction of the medial

Collateral ligaments and medial meniscus in rats

⊕ Psoriasis

Xenogenic transplantation approach, Imiquimod-induced psoriasis

⊕ Multiple Sclerosis models

Induction of EAE in mice by spinal cord homogenates

Induction of EAE by MOG35-55 in mice

In-vitro inflammatory models

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LPS stimulation of murine macrophage cells

In vitro screening for inhibition of nitric oxide (NO) production in RAW 264.7 cells

Generation of organotypic LPS induced brain slices

Bead-based Multiplex Assay.