4P Pharma offers a wide range of preclinical inflammatory models and consultancy expertise in the preclinical inflammatory area. We develop flexible, tailored preclinical programs designed to each therapeutics specificity, from in vitro drug screening to experimental inflammatory models in animals.
Acute and chronic inflammation are the cause of severe complications and an established risk factor for life-threatening conditions, including cancer, cardiovascular diseases and stroke.
For every R&D studies performed, we ensure an intercross between in vitro, in vivo and ex vivo models along with unbiased laboratory, species and model independency.
Acute inflammation models
Carrageenan-induced acute inflammation model in rats
Formalin induced sub-acute inflammation test in mice
Cotton pellet-induced granuloma test in rats
Delayed-type hypersensitivity model in mice (DTH)
Peritonitis model in mice (Macrophages Migration)
Lung fibrosis model in mice (Bleomycin induced)
Corton oil induced ear inflammation
Chronic inflammation models
⊕ Intestinal Bowel Disease Models
DSS-induced colitis in mice (Balb/c, C57Bl/6)
TNBS-induced colitis in mice
⊕ Rheumatoid Arthritis models
Collagen-induced arthritis model in rats/mice
⊕ Osteoarthritis models
CFA-induced osteoarthritis model in rats
Induction of osteoarthritis model by transaction of the medial
Collateral ligaments and medial meniscus in rats
Xenogenic transplantation approach, Imiquimod-induced psoriasis
⊕ Multiple Sclerosis models
Induction of EAE in mice by spinal cord homogenates
Induction of EAE by MOG35-55 in mice
In-vitro inflammatory models
LPS stimulation of murine macrophage cells
In vitro screening for inhibition of nitric oxide (NO) production in RAW 264.7 cells
Generation of organotypic LPS induced brain slices
Bead-based Multiplex Assay.